Scientific Resources on Hypertension and Aldosterone

Scientific Resources

Explore our library of educational resources to dive deeper into the role of aldosterone in uncontrolled hypertension and its effects on end-organ damage.

Scientific Resources

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Recommended Reading

Global Report on Hypertension 2025: High Stakes: Turning Evidence into Action

Agboyibor K, et al. World Health Organization 2025 [Available online at https://www.who.int/publications/i/item/9789240115569] (Accessed April 2026)

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Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline

Adler GK, et al. J Clin Endocrinol Metab 2025;110:2453–2495

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Hypertension in CKD: Core Curriculum 2019

Ku E, et al. Am J Kidney Dis 2019;74:120–131

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Primary Aldosteronism: State-of-the-Art Review

Vaidya A, et al. Am J Hypertens 2022;35:967–988

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Relationship Between Renin, Aldosterone, Aldosterone-to-Renin Ratio and Arterial Stiffness and Left Ventricular Mass Index in Young Adults

Ananda RA, et al. Circulation AHA 2024;150:2019–2030

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Risk of Hypertension and Chronic Kidney Disease Following Aldosterone Dysregulation

Townsend R, et al. Am J Hypertens 2026;39:161–170

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Obesity, Aldosterone Excess, and Mineralocorticoid Receptor Activation: Parallel or Intersected Circumstances?

Puzantian H, et al. J Clin Hypertens 2024;26:1384–1390

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Salt and Aldosterone – Reciprocal and Combined Effects in Preclinical Models and Humans

Chen L, et al. Horm Metab Res 2024;56:99–106

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Aldosterone and Cardiovascular Diseases

Parksook WW, Williams GH. Cardiovasc Res 2023;119:28–44

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Aldosterone in Chronic Kidney Disease and Renal Outcomes

Verma A, et al. Eur Heart J 2022;43:3781–3791

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Endocrine and Haemodynamic Changes in Resistant Hypertension, and Blood Pressure Responses to Spironolactone or Amiloride: The PATHWAY-2 Mechanisms Substudies

Williams B, et al. Lancet Diabetes Endocrinol 2018;6:464–475

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Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study

Goupil R, et al. Circulation 2025;152:913–923

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Aldosterone and Cardiovascular Risk Across the Lifespan

Ananda R, et al. Metabolites 2025;15:533

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Characterizing the Origins of Primary Aldosterone

Brown JM, et al. Hypertension 2025;82:306–318

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Renin-Aldosterone Profiles and Cardiorenal Outcomes in Hypertension: A Nationwide Cohort Study

Ljundberg C, et al. JACC 2026;Mar 25:S0735-1097(26)00235

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Unmasking Hormonal Mechanisms of Hypertension in Obesity

Parisien-La Salle S, et al. JACC Basic Transl Sci. 2026;11;101526

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The Unrecognized Prevalence of Primary Aldosteronism: A Cross-sectional Study

Brown JM, et al. Ann Intern Med 2020;173:10–20

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Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study

Hundemer GL, et al. Circulation 2024;149:124–134

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The Spectrum of Dysregulated Aldosterone Production: An International Human Physiology Study

Parksook WW, et al. J Clin Endocrinol Metab 2024;109:2220–2232

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Scientific Resource Library

This list of scientific resources and publications, curated by experts, highlights the growing body of evidence linking aldosterone with hypertension and cardiovascular and kidney risk.